BSCC Christmas seminar: Anne Mette Søviknes

We would like to invite you to the BSCC Christmas seminar on Friday, December 15th, 12:00 o’clock at Birkhaugsalen. For details, please see the attached poster. 

Please share with your colleagues and students, and show your support by attending the seminar.

 

2017-12-15 BSCC Christmas seminar 2017

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Stamcelleforskning – i dag og i morgen

Program for stamcelleforskning (2013–2017) har hatt som mål å utvikle og styrke kompetansen innenfor grunnleggende og klinisk forskning på stamceller, med sikte på behandling av alvorlig og kronisk syke pasienter.

Programmet har hatt tre hovedpilarer: Støtte til prosjekter basert på åpen konkurransebasert utlysning av forsknings- midler, bevilgning til Nasjonalt senter for stamcelleforskning, og finansiering av det årlige nettverksmøtet for norsk stamcelleforskning. Programstyret har gjennom disse virkemidlene bygget opp norsk stamcelleforskning.

Programmet har hatt fire prioriterte tematiske områder:
• Forskning for bedre forståelse av basale prosesser knyttet til vekst og differensiering av stamceller.
• Karakterisering og validering av stamceller for bruk i klinikken.
• Utvikling og implementering av prosedyrer og protokoller for reparasjon av skadet vev eller organ.
• Bruk og videreutvikling av induserte pluripotente stamceller (iPS-celler).

Mer informasjon på programmets hjemmeside.

Formidlingsbrosjyre Program for stamcelleforskning

 

 

Laurence Hoareau and Manuel Carrasco joined the lab

We are welcoming two new postdoctoral fellows to our research group.

Laurence Hoareau is a scientist in cell biology, molecular biology and biochemistry. She has been working for 10 years in the field of adipose tissue inflammation linked to obesity-associated diseases. Her work is essentially based on human primary culture of adipose tissue, adipocytes and stromal cells, which lead to around 20 publications. Laurence is from Reunion Island (French overseas department in Indian Ocean). She obtained her Bachelor’s degree from University of Reunion Island, her Master degree from University Pierre & Marie Curie (Paris, France) and her Ph.D in Biochemistry, Molecular and Cellular Biology from University of Reunion Island.

Manuel Carrasco recently obtained his PhD from the Andalusian Molecular Biology and Regenerative Medicine Centre in Seville, Spain. Manuel’s research was focused on how transcriptional networks control pancreas and liver development and function by using mouse models (conditional knockout mice, reporter transgenic lines, cell culture, etc.). More specifically, Manuel studied the contribution of GATA transcription factors to pancreas organogenesis, regeneration and function. Manuel obtained his Bachelor degree from University of Seville and his Master degree from University Pablo de Olavide (Sevilla, Spain).

IMG_0262

Laurence Hoareau and Manuel Carrasco enjoying our first “get-together” dinner

Our confocal is in place!

After more than 6 months of waiting, planing, arguing, more planing, we have our own old but still functional SP2 Leica confocal set in place. Of course, we lost some screws during its movement, but thanks to the great administrative skills of Helge, we have now all that is needed.  So, I have many thanks for:

  • Helge and Simona, which convinced the MIC platform not to retire this great machine (my favourite), and we promise that we’ll still use the MIC confocals (ofc, they have SP5 and SP8!);
  • MIC people, especially Hege and Endy, which took really good care of this machine that is now in our care;
  • Bård-Arne Pedersen from Ortomedic, which managed to put all the pieces back together in ONE day! 

    IMG_9915

Norwegian Press Reviews

We are very grateful and happy to announce that our research article was discussed in several interviews, where Helge explained the current status of diabetes research and our contribution. You can find the the press articles (in Norwegian) below:

Screen Shot 2017-08-21 at 16.46.52

interview for nrk

interview for forskning.no

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Screen Shot 2017-08-16 at 14.32.28

 

 

New Article: Scientific Reports

Maturity-onset diabetes of the young (MODY) is one of the hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. Patients with MODY1 typically develops diabetes (persistent hyperglycemia) before the age of 25 years, but this may not appear until later decades. The degree of insulin deficiency is slowly progressive. Many patients with MODY1 are treated with sulfonylureas for years before insulin is required.

MODY 1 is caused by a loss-of-function mutation in the HNF4α gene. HNF4α is part of a transcription network, including HNF1α (responsible for MODY3) and perhaps HNF1β (MODY5 – see Early Developmental Perturbations in a Human Stem Cell Model of MODY5/HNF1B Pancreatic Hypoplasia), which plays a role in the early development of the pancreas, liver, and intestines. In the pancreas these genes influence the expression of insulin, the principal glucose transporter (GLUT2), and several proteins involved in glucose and mitochondrial metabolism.

We used a combination of global proteomics and cellular biology techniques to investigate the differentiation capacity of insulin-producing cells using a seven-step differentiation protocol (as established by Rezania et al.) of induced pluripotent stem cells, generated from either healthy subjects or MODY1 patients.

Our data show that a human HNF4A mutation is neither blocking the expression of the insulin genes nor the development of insulin-producing cells in vitro. Our analyses also suggest key developmental signalling pathways representing potential targets for improving the efficiency of the current differentiation protocols.

Future studies are required on improving later differentiation stages up to mature insulin-producing β-like cells, which should also reveal the impact of HNF4A-directed transcriptional perturbations on β-cell survival and function.

The paper can be read here.

Probing the missing mature β-cell proteomic landscape in differentiating patient iPSC-derived cells Heidrun Vethe, Yngvild Bjørlykke, Luiza M. Ghila, Joao A. Paulo, Hanne Scholz, Steven P. Gygi, Simona Chera & Helge Ræder
Scientific Reports.2017 Jul 6;7(1):4780. doi: 10.1038/s41598-017-04979-w.