Scientific day at KG Jebsen Center for Diabetes Research

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This year’s Autumn meeting was held at Urdihuset in Bergen and had as a theme Clinics meet basics. After a delicious get-together soup lunch, the meeting was opened by Pål R. Njølstad, who shared some positive comments about the work and the activities of the KG Jebsen Center for Diabetes Research and bid welcome to the eight new members.

The scientific presentations series started by Bente B. Johansson, who also talked at the EASD meeting in Stockholm about the prevalence of monogenic diabetes in the Norwegian Childhood Diabetes Registry estimated by targeted deep sequencing. Her data further support the need for personalized medical treatment as some children with diabetes 1 might have a genetic type where they can use sulfonylurea tablets instead of insulin injections.

Åsta Sulen presented very interesting data about the neurological and metabolic aspects in children with neonatal diabetes treated with sulfonylurea for 10 years.

After lots of coffee, the second session was chaired by Simona Chera and started with an overview presented by Øyvind Helgeland on quality control steps in genotypic data. His presentation showed very clearly the importance of good input data and the tedious work necessary to organize large scale studies based on questionnaire filled by participants.

Marie Solheim presented a new mouse model of SHORT syndrome caring a mutation in PI3K. This mouse model is based on a gene mutation found in a Norwegian family with diabetes. She also presented her research at EASD: impaired PI 3-kinase signalling in a mouse model of SHORT syndrome.

Eva Ringdal Pedersen and Elin Strand discussed about the importance of the kynurenine pathway in T2D patients and its correlations in rats treated with PPAR agonists.

The third session, chaired by Gunnar Mellgren, focused on adipocytes, obesity and lipogenesis. Simon Dankel presented very interesting data about the importance of an amino acid transporter, SLC7A10, in adipocyte energy metabolism and insulin resistance. Johan Fernø made a nice review on the relation between immune and fat cells, suggesting a cause-effect on insulin resistance in metabolic unhealthy obese individuals. The last talk, before the networking dinner, was on SRC-2, which regulates hepatic gluconeogenesis and lipogenesis, by André Madsen.

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